SLC45A3-ELK4 chimera in prostate cancer: spotlight on cis-splicing.
نویسندگان
چکیده
Using a series of detailed experiments, Zhang and colleagues establish that the prostate cancer RNA chimera SLC45A3-ELK4 is generated by cis-splicing between the 2 adjacent genes and does not involve DNA rearrangements or trans-splicing. The chimera expression is induced by androgen treatment likely by overcoming the read-through block imposed by the intergenic CCCTC insulators bound by CCCTC-binding factor repressor protein. The chimeric transcript, but not wild-type ELK4, is shown to augment prostate cancer cell proliferation.
منابع مشابه
Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation.
UNLABELLED Gene fusion is a common event in cancer. The fusion RNA and protein products often play causal roles in tumorigenesis and therefore represent ideal diagnostic and therapeutic targets. Formerly, fusion chimeric products in cancer were thought to be produced solely by chromosomal translocation. Here, we show that a chimeric SLC45A3-ELK4 RNA is generated in the absence of chromosomal re...
متن کاملIN THE SPOTLIGHT SLC45A3-ELK4 Chimera in Prostate Cancer: Spotlight on cis-Splicing
Authors’ Affi liations: 1Michigan Center for Translational Pathology, Departments of 2Pathology and 3Urology, 4Comprehensive Cancer Center, and 5Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan Corresponding Author: Arul M. Chinnaiyan, University of Michigan, 1400 E. Medical Center Dr. 5316 CCGC 5940, Ann Arbor, MI 48109. Phone: 734615-4062; Fax: 734-6...
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In humans, more than 30,000 chimeric transcripts originating from 23,686 genes have been identified. The mechanisms and association of chimeric transcripts arising from chromosomal rearrangements with cancer are well established, but much remains unknown regarding the biogenesis and importance of other chimeric transcripts that arise from nongenomic alterations. Recently, a SLC45A3-ELK4 chimera...
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عنوان ژورنال:
- Cancer discovery
دوره 2 7 شماره
صفحات -
تاریخ انتشار 2012